Mar 22, 2023
AP 873 - Physiologically Based Pharmacokinetic ModelingCredits: 4
This modeling course is designed for life science graduate students with an interest in computational toxicology and pharmacology. Development of physiologically based pharmacokinetic (PBPK) models for environmental chemicals, drugs, and nanomaterials in laboratory animals, food-producing animals, companion animals, and/or humans will be introduced. Applications of PBPK models in food safety, toxicology, risk assessment, and pharmaceutical industry will be discussed. This course will cover theory, application software, experimental design, model development, optimization, validation, evaluation, and extrapolation. The expected outcome is that the student will have PBPK modeling knowledge and skills to develop a PBPK model with some mentoring from an experienced PBPK modeler. Format will include both weekly lectures and hands-on computer lab exercises.
(1) To provide the student with working knowledge of physiologically based pharmacokinetic models and their applications in toxicology
(2) To provide students with the technical ability to develop PBPK models for use in their graduate research and careers
(1) Grades will be determined from two written tests (20% each), computer lab simulation exercises/assignments (20%), a project presentation which demonstrates the development of a PBPK model and the application of the PBPK model in toxicology (40%).
(2) All grading will be administered through K-State online.
Prerequisite: Consent of instructor and 1 semester of calculus, physiology, pharmacology, pharmacokinetics, toxicology or biochemistry.
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